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The data presented here suggest that Nle1-AngIV and Dihexa increase miniature synaptic activity by increasing dendritic spine densities and altering the morphological phenotype of postsynaptic spines in-vitro and may represent the mechanism that underlies facilitated learning observed AngIV analogues (Wright, Stubley et al
While the majority of evidence remains preclinical, three small pilot studies have now been published in humans, and a Phase 2 randomized controlled trial (NCT07437547) is currently recruiting for hamstring muscle strain repair
doi:10.1056/NEJM198806303182604
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